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Staff Profiles

Dr Paul Sheridan

BA., PhD

Biography

Lecturer in Microbiology
Principal Investigator, Microbial Genomics Group
School of Biological and Chemical Sciences
Email: paul.sheridan@universityofgalway.ie

2022-Present: Lecturer in Microbiology, University of Galway, Ireland

2022-Present: Honorary Lecturer in Biological Sciences, University of Aberdeen

2018-2022: Research Fellow, School of Biological Sciences, University of Aberdeen

2015-2018: Research Fellow, Rowett Institute, University of Aberdeen

2014: PhD., Microbiology, University of Aberdeen 2014

2010: B.A. (Mod), Microbiology, Trinity College Dublin, University of Dublin

Dr Paul Sheridan is the Principal Investigator of the Microbial Genomics Group and a Lecturer in Microbiology at the University of Galway. His research uses state-of-the-art genomics and experimental microbiology to improve our understanding of the microbial world and its influence on agriculture, environmental protection, and human health. His research utilizes a combined computation and experimental approach to uncover the fundamental principles of microbial evolution, ecology, and physiology. Throughout his career, Dr Sheridan has studied a wide variety bacteria and archaea from soil, plants, rivers, geothermal vents, marine sponge, aquaculture, livestock, and the human gut.

Research Interests

Microbes in agriculture and environmental protection
Microbial physiology and metabolism
Microbial habitat transition

Comparative genomics and phylogenomics

Microbial evolution and ecology

Genome-resolved and functional metagenomics

Peer Reviewed Journals

	Year	Publication
	(2023)	'Establishing genetic manipulation for novel strains of human gut bacteria' Sheridan, P.O and Odat M.A and Scott K.P (2023) 'Establishing genetic manipulation for novel strains of human gut bacteria'. [Details]
	(2023)	'Genomics of soil depth niche partitioning in the Thaumarchaeota family Gagatemarchaeaceae' Sheridan, P.O. and Meng, Y and Williams, T.A. and Gubry-Rangin, C (2023) 'Genomics of soil depth niche partitioning in the Thaumarchaeota family Gagatemarchaeaceae'. Nature Communications, 14 (1) [Details]
	(2022)	'Recovery of Lutacidiplasmatales archaeal order genomes suggests convergent evolution in Thermoplasmatota' Sheridan, P.O. and Meng, Y. and Williams, T.A. and Gubry-Rangin, C. (2022) 'Recovery of Lutacidiplasmatales archaeal order genomes suggests convergent evolution in Thermoplasmatota'. Nature Communications, 13 (1) [DOI] [Details]
	(2022)	'Rooting Species Trees Using Gene Tree-Species Tree Reconciliation' Harris, B.J. and Sheridan, P.O. and DavÃn, A.A. and Gubry-Rangin, C. and SzÃ¶llÅ‘si, G.J. and Williams, T.A. (2022) 'Rooting Species Trees Using Gene Tree-Species Tree Reconciliation'. Methods in Molecular Biology, 2569 :189-211 [DOI] [Details]
	(2022)	'Distribution, organization and expression of genes concerned with anaerobic lactate utilization in human intestinal bacteria' Sheridan, P.O. and Louis, P. and Tsompanidou, E. and Shaw, S. and Harmsen, H.J. and Duncan, S.H. and Flint, H.J. and Walker, A.W. (2022) 'Distribution, organization and expression of genes concerned with anaerobic lactate utilization in human intestinal bacteria'. Microbial Genomics, 8 (1) [DOI] [Details]
	(2020)	'Gene duplication drives genome expansion in a major lineage of Thaumarchaeota' Sheridan, P.O. and Raguideau, S. and Quince, C. and Holden, J. and Zhang, L. and Gaze, W.H. and Holden, J. and Mead, A. and Raguideau, S. and Quince, C. and Singer, A.C. and Wellington, E.M.H. and Zhang, L. and Williams, T.A. and Gubry-Rangin, C. (2020) 'Gene duplication drives genome expansion in a major lineage of Thaumarchaeota'. Nature Communications, 11 (1) [DOI] [Details]
	(2019)	'Heterologous gene expression in the human gut bacteria Eubacterium rectale and Roseburia inulinivorans by means of conjugative plasmids' Sheridan, P.O. and Martin, J.C. and Minton, N.P. and Flint, H.J. and O'Toole, P.W. and Scott, K.P. (2019) 'Heterologous gene expression in the human gut bacteria Eubacterium rectale and Roseburia inulinivorans by means of conjugative plasmids'. Anaerobe, 59 :131-140 [DOI] [Details]
	(2018)	'Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota' Chung, W.S.F. and Walker, A.W. and Vermeiren, J. and Sheridan, P.O. and Bosscher, D. and Garcia-Campayo, V. and Parkhill, J. and Flint, H.J. and Duncan, S.H. (2018) 'Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota'. FEMS Microbiology Ecology, 95 (1) [DOI] [Details]
	(2018)	'Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii' Mukhopadhya, I. and MoraÃ¯s, S. and Laverde-Gomez, J. and Sheridan, P.O. and Walker, A.W. and Kelly, W. and Klieve, A.V. and Ouwerkerk, D. and Duncan, S.H. and Louis, P. and Koropatkin, N. and Cockburn, D. and Kibler, R. and Cooper, P.J. and Sandoval, C. and Crost, E. and Juge, N. and Bayer, E.A. and Flint, H.J. (2018) 'Sporulation capability and amylosome conservation among diverse human colonic and rumen isolates of the keystone starch-degrader Ruminococcus bromii'. Environmental Microbiology, 20 (1):324-336 [DOI] [Details]
	(2016)	'Objections to the proposed reclassification of eubacterium rectale as agathobacter rectalis' Sheridan, P.O. and Duncan, S.H. and Walker, A.W. and Scott, K.P. and Louis, P. and Flint, H.J. (2016) 'Objections to the proposed reclassification of eubacterium rectale as agathobacter rectalis'. International Journal of Systematic and Evolutionary Microbiology, 66 (5) [DOI] [Details]
	(2016)	'Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic firmicutes' Sheridan, P.O. and Martin, J.C. and Lawley, T.D. and Browne, H.P. and Harris, H.M.B. and Bernalier-Donadille, A. and Duncan, S.H. and Oâ€™Toole, P.W. and Scott, K.P. and Flint, H.J. (2016) 'Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic firmicutes'. Microbial Genomics, 2 (2):1-16 [DOI] [Details]
	(2015)	'Unique organization of extracellular amylases into amylosomes in the resistant starch-utilizing human colonic firmicutes bacterium ruminococcus bromii' Ze, X. and David, Y.B. and Laverde-Gomez, J.A. and Dassa, B. and Sheridan, P.O. and Duncan, S.H. and Louis, P. and Henrissat, B. and Juge, N. and Koropatkin, N.M. and Bayer, E.A. and Flint, H.J. (2015) 'Unique organization of extracellular amylases into amylosomes in the resistant starch-utilizing human colonic firmicutes bacterium ruminococcus bromii'. mBio, 6 (5) [DOI] [Details]
	(2013)	'Can prebiotics and probiotics improve therapeutic outcomes for undernourished individuals?' Sheridan, P.O. and Bindels, L.B. and Saulnier, D.M. and Reid, G. and Nova, E. and Holmgren, K. and O'Toole, P.W. and Bunn, J. and Delzenne, N. and Scott, K.P. (2013) 'Can prebiotics and probiotics improve therapeutic outcomes for undernourished individuals?'. Gut Microbes, 5 (1):74-82 [DOI] [Details]
	(2013)	'Pro-Inflammatory Flagellin Proteins of Prevalent Motile Commensal Bacteria Are Variably Abundant in the Intestinal Microbiome of Elderly Humans' Neville, B.A. and Sheridan, P.O. and Harris, H.M.B. and Coughlan, S. and Flint, H.J. and Duncan, S.H. and Jeffery, I.B. and Claesson, M.J. and Ross, R.P. and Scott, K.P. and O'Toole, P.W. (2013) 'Pro-Inflammatory Flagellin Proteins of Prevalent Motile Commensal Bacteria Are Variably Abundant in the Intestinal Microbiome of Elderly Humans'. PLoS ONE, 8 (7) [DOI] [Details]
	(2013)	'The influence of diet on the gut microbiota' Scott, K.P. and Gratz, S.W. and Sheridan, P.O. and Flint, H.J. and Duncan, S.H. (2013) 'The influence of diet on the gut microbiota'. Pharmacological Research, 69 (1):52-60 [DOI] [Details]